Deep brain stimulation of the periaqueductal gray releases endogenous opioids in humans.

ABSTRACT: Deep brain stimulation (DBS) of the periaqueductal gray (PAG) is used in the treatment of severe refractory neuropathic pain. We tested the hypothesis that DBS releases endogenous opioids to exert its analgesic effect using [¹¹C]diprenorphine (DPN) positron emission tomography (PET). Patients with de-afferentation pain (phantom limb pain or Anaesthesia Dolorosa (n=5)) who obtained long-lasting analgesic benefit from DBS were recruited. [¹¹C]DPN and [¹⁵O]water PET scanning was performed in consecutive sessions; first without, and then with PAG stimulation. The regional cerebral tracer distribution and kinetics were quantified for the whole brain and brainstem. Analysis was performed on a voxel-wise basis using statistical parametric mapping (SPM) and also wi

SUBMITTER: Sims-Williams H 

PROVIDER: S-EPMC5312788 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature