Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial.

ABSTRACT:

Importance

Whole brain radiotherapy (WBRT) significantly improves tumor control in the brain after stereotactic radiosurgery (SRS), yet because of its association with cognitive decline, its role in the treatment of patients with brain metastases remains controversial.

Objective

To determine whether there is less cognitive deterioration at 3 months after SRS alone vs SRS plus WBRT.

Design, setting, and participants

At 34 institutions in North America, patients with 1 to 3 brain metastases were randomized to receive SRS or SRS plus WBRT between February 2002 and December 2013.

Interventions

The WBRT dose schedule was 30 Gy in 12 fractions; the SRS dose was 18 to 22 Gy in the SRS plus WBRT group and 20 to 24 Gy for SRS alone.

Main outcomes and measures

The

SUBMITTER: Brown PD 

PROVIDER: S-EPMC5313044 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature