Heparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c.

ABSTRACT: A small library of well defined heparan sulfate (HS) polysaccharides was chemoenzymatically synthesized and used for a detailed structure-activity study of fibroblast growth factor (FGF) 1 and FGF2 signaling through FGF receptor (FGFR) 1c. The HS polysaccharide tested contained both undersulfated (NA) domains and highly sulfated (NS) domains as well as very well defined non-reducing termini. This study examines differences in the HS selectivity of the positive canyons of the FGF1₂-FGFR1c₂ and FGF2₂-FGFR1c₂ HS binding sites of the symmetric FGF₂-FGFR₂-HS₂ signal transduction complex. The results suggest that FGF1₂-FGFR1c₂ binding site prefers a longer NS domain at the non-reducing terminus tha

SUBMITTER: Schultz V 

PROVIDER: S-EPMC5313116 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature