The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis.

ABSTRACT:

Background

The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS.

Objective

To perform a systematic review and meta-analysis and to assess qualitative and quantitative evidence on the expression of HERV families in MS patients.

Methods

Medline, Embase and the Cochrane Library were searched for published studies on the association of HERVs and MS. Meta-analysis was performed on the HERV-W family. Odds Ratio (OR) and 95% confidence interval (CI) were calculated for association.

Results

43 reports were extracted (25 related to HERV-W, 13 to HERV-H, 9 to HERV-K, 5 to HRES-1 and 1 to HE

SUBMITTER: Morandi E 

PROVIDER: S-EPMC5313176 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature