Sunitinib: Ten Years of Successful Clinical Use and Study in Advanced Renal Cell Carcinoma.

ABSTRACT: The oral multikinase inhibitor sunitinib malate was approved by the U.S. Food and Drug Administration in January 2006 for use in patients with advanced renal cell carcinoma (RCC). Since then, it has been approved globally for this indication and for patients with imatinib-resistant or -intolerant gastrointestinal stromal tumors and advanced pancreatic neuroendocrine tumors. As we mark the 10-year anniversary of the beginning of the era of targeted therapy, and specifically the approval of sunitinib, it is worthwhile to highlight the progress that has been made in advanced RCC as it relates to the study of sunitinib. We present the key trials and data for sunitinib that established it as a reference standard of care for first-line advanced RCC therapy and, along with other targeted agents,

SUBMITTER: Motzer RJ 

PROVIDER: S-EPMC5313263 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature