Upregulation of long noncoding RNA TUG1 promotes cervical cancer cell proliferation and migration.

ABSTRACT: Long noncoding RNAs (lncRNAs), a novel class of transcripts that have critical roles in carcinogenesis and progression, have emerged as important gene expression modulators. Recent evidence indicates that lncRNA taurine-upregulated gene 1 (TUG1) functions as an oncogene in numerous types of human cancers. However, its function in the development of cervical cancer remains unknown. The aim of this research was to investigate the clinical significance and biological functions of TUG1 in cervical cancer. TUG1 was found to be significantly upregulated in cervical cancer tissues and four cervical cancer cell lines by quantitative real-time polymerase chain reaction (qRT-PCR). Elevated TUG1 expression was correlated with larger tumor size, advanced international federation of gynecology and obst

SUBMITTER: Hu Y 

PROVIDER: S-EPMC5313648 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature