Identification of Distinct Psychosis Biotypes Using Brain-Based Biomarkers.

ABSTRACT:

Objective

Clinical phenomenology remains the primary means for classifying psychoses despite considerable evidence that this method incompletely captures biologically meaningful differentiations. Rather than relying on clinical diagnoses as the gold standard, this project drew on neurobiological heterogeneity among psychosis cases to delineate subgroups independent of their phenomenological manifestations.

Method

A large biomarker panel (neuropsychological, stop signal, saccadic control, and auditory stimulation paradigms) characterizing diverse aspects of brain function was collected on individuals with schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis (N=711), their first-degree relatives (N=883), and demographically comparable healthy subjects (

SUBMITTER: Clementz BA 

PROVIDER: S-EPMC5314432 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature