Proximity to a Major Road and Plasma Cytokines in School-Aged Children.

ABSTRACT: Traffic-related air pollution (TRAP) may affect immune responses, including those in the T_H2 and T_H17 pathways. To examine whether TRAP is associated with plasma level of T_H17-, T_H1-, and T_H2-related cytokines in children with and without asthma, a cross-sectional study of 577 children (ages 6-14 years) with (n = 294) and without (n = 283) asthma in San Juan (Puerto Rico) was performed. Residential distance to a major road was estimated using geocoded home addresses for study participants. A panel of 14 cytokines, enriched for the T_H17 pathway, was measured in plasma. Asthma was defined as physician-diagnosed asthma and current wheeze. Multivariable linear regression was used to examine the association of resid

SUBMITTER: Rosser F 

PROVIDER: S-EPMC5314728 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature