¹H NMR-based serum metabolomics reveals erythromycin-induced liver toxicity in albino Wistar rats.

ABSTRACT:

Introduction

Erythromycin (ERY) is known to induce hepatic toxicity which mimics other liver diseases. Thus, ERY is often used to produce experimental models of drug-induced liver-toxicity. The serum metabolic profiles can be used to evaluate the liver-toxicity and to further improve the understanding of underlying mechanism.

Objective

To establish the serum metabolic patterns of Erythromycin induced hepatotoxicity in albino wistar rats using ¹H NMR based serum metabolomics.

Experimental

Fourteen male rats were randomly divided into two groups (n = 7 in each group): control and ERY treated. After 28 days of intervention, the metabolic profiles of sera obtained from ERY and control groups were analyzed using high-resolution 1D ¹H CPMG and d

SUBMITTER: Rawat A 

PROVIDER: S-EPMC5314833 | biostudies-literature | 2016 Oct-Dec

REPOSITORIES: biostudies-literature