Risk analysis of colorectal cancer incidence by gene expression analysis.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the leading cancers worldwide. Several studies have performed microarray data analyses for cancer classification and prognostic analyses. Microarray assays also enable the identification of gene signatures for molecular characterization and treatment prediction.

Objective

Microarray gene expression data from the online Gene Expression Omnibus (GEO) database were used to to distinguish colorectal cancer from normal colon tissue samples.

Methods

We collected microarray data from the GEO database to establish colorectal cancer microarray gene expression datasets for a combined analysis. Using the Prediction Analysis for Microarrays (PAM) method and the GSEA MSigDB resource, we analyzed the 14,698 genes that were identified thr

SUBMITTER: Shangkuan WC 

PROVIDER: S-EPMC5314952 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature