Effect of interleukin (IL)-35 on IL-17 expression and production by human CD4⁺ T cells.

ABSTRACT:

Background

Interleukin (IL)-17 produced by mainly T helper 17 (Th17) cells may play an important destructive role in chronic periodontitis (CP). Thus, anti-inflammatory cytokines, such as IL-35, might have a beneficial effect in periodontitis by inhibiting differentiation of Th17 cells. Th17 differentiation is regulated by the retinoic acid receptor-related orphan receptor (ROR) α (encoded by RORA) and RORγt (encoded by RORC). However, the role of IL-35 in periodontitis is not clear and the effect of IL-35 on the function of Th17 cells is still incompletely understood. Therefore, we investigated the effects of IL-35 on Th17 cells.

Methods

Peripheral blood mononuclear cells (PBMCs) were sampled from three healthy volunteers and three CP patients an

SUBMITTER: Okada K 

PROVIDER: S-EPMC5314955 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature