Repeated short climatic change affects the epidermal differentiation program and leads to matrix remodeling in a human organotypic skin model.

ABSTRACT: Human skin is subject to frequent changes in ambient temperature and humidity and needs to cope with these environmental modifications. To decipher the molecular response of human skin to repeated climatic change, a versatile model of skin equivalent subject to "hot-wet" (40°C, 80% relative humidity [RH]) or "cold-dry" (10°C, 40% RH) climatic stress repeated daily was used. To obtain an exhaustive view of the molecular mechanisms elicited by climatic change, large-scale gene expression DNA microarray analysis was performed and modulated function was determined by bioinformatic annotation. This analysis revealed several functions, including epidermal differentiation and extracellular matrix, impacted by repeated variations in climatic conditions. Some of these molecular changes were confirm

SUBMITTER: Boutrand LB 

PROVIDER: S-EPMC5315211 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature