Interaction between smoking and body mass index and risk of oral clefts.

ABSTRACT:

Purpose

To examine maternal smoking and body mass index (BMI) interactions in contributing to risk of oral clefts.

Methods

We studied 4935 cases and 10,557 controls from six population-based studies and estimated a pooled logistic regression of individual-level data, controlling for study fixed effects and individual-level risk factors.

Results

We found a significant negative smoking-BMI interaction, with cleft risk with smoking generally declining with higher BMI. For all clefts combined, the odds ratio for smoking was 1.61 (95% confidence interval [CI]: 1.39-1.86) at BMI 17 (underweight), 1.47 (95% CI: 1.34-1.62) at BMI 22 (normal weight), 1.35 (95% CI: 1.22-1.48) at BMI 27 (overweight), 1.21 (95% CI: 1.04-1.41) at BMI 33 (obese), and 1.13 (95% CI: 0.92-1.38) at BMI

SUBMITTER: Wehby GL 

PROVIDER: S-EPMC5315269 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature