Long term effects of fetal undernutrition on rat heart. Role of hypertension and oxidative stress.

ABSTRACT:

Background and aims

Fetal undernutrition is a risk factor for heart disease in both genders, despite the protection of women against hypertension development. Using a rat model of maternal undernutrition (MUN) we aimed to assess possible sex differences in the development of cardiac alterations and the implication of hypertension and cardiac oxidative stress.

Methods

Male and female offspring from rats fed ad libitum (control) or with 50% of the normal daily intake during the second half of gestation (MUN) were used. Heart weight/body weight ratio (HW/BW), hemodynamic parameters (anaesthetized rats) and plasma brain natriuretic peptide (BNP, ELISA) were assessed in 21-day, 6-month and 22-month old rats. Plasma testosterone (ELISA) and cardiac protein expression of enzymes re

SUBMITTER: Rodriguez-Rodriguez P 

PROVIDER: S-EPMC5315302 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature