ASPASIA: A toolkit for evaluating the effects of biological interventions on SBML model behaviour.

ABSTRACT: A calibrated computational model reflects behaviours that are expected or observed in a complex system, providing a baseline upon which sensitivity analysis techniques can be used to analyse pathways that may impact model responses. However, calibration of a model where a behaviour depends on an intervention introduced after a defined time point is difficult, as model responses may be dependent on the conditions at the time the intervention is applied. We present ASPASIA (Automated Simulation Parameter Alteration and SensItivity Analysis), a cross-platform, open-source Java toolkit that addresses a key deficiency in software tools for understanding the impact an intervention has on system behaviour for models specified in Systems Biology Markup Language (SBML). ASPASIA can generate and mod

SUBMITTER: Evans S 

PROVIDER: S-EPMC5315406 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature