The effective rate of influenza reassortment is limited during human infection.

ABSTRACT: We characterise the evolutionary dynamics of influenza infection described by viral sequence data collected from two challenge studies conducted in human hosts. Viral sequence data were collected at regular intervals from infected hosts. Changes in the sequence data observed across time show that the within-host evolution of the virus was driven by the reversion of variants acquired during previous passaging of the virus. Treatment of some patients with oseltamivir on the first day of infection did not lead to the emergence of drug resistance variants in patients. Using an evolutionary model, we inferred the effective rate of reassortment between viral segments, measuring the extent to which randomly chosen viruses within the host exchange genetic material. We find strong evidence that the

SUBMITTER: Sobel Leonard A 

PROVIDER: S-EPMC5315410 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature