Cognitive impairment and decline in cognitively normal older adults with high amyloid-β: A meta-analysis.

ABSTRACT:

Introduction

This meta-analysis aimed to characterize the nature and magnitude of amyloid (Aβ)-related cognitive impairment and decline in cognitively normal (CN) older individuals.

Method

MEDLINE Ovid was searched from 2012 to June 2016 for studies reporting relationships between cerebrospinal fluid or positron emission tomography (PET) Aβ levels and cognitive impairment (cross-sectional) and decline (longitudinal) in CN older adults. Neuropsychological data were classified into domains of episodic memory, executive function, working memory, processing speed, visuospatial function, semantic memory, and global cognition. Type of Aβ measure, how Aβ burden was analyzed, inclusion of control variables, and clinical criteria used to exclude participants, were considered as moder

SUBMITTER: Baker JE 

PROVIDER: S-EPMC5315443 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature