Combining contact tracing with targeted indoor residual spraying significantly reduces dengue transmission.

ABSTRACT: The widespread transmission of dengue viruses (DENV), coupled with the alarming increase of birth defects and neurological disorders associated with Zika virus, has put the world in dire need of more efficacious tools for Aedes aegypti-borne disease mitigation. We quantitatively investigated the epidemiological value of location-based contact tracing (identifying potential out-of-home exposure locations by phone interviews) to infer transmission foci where high-quality insecticide applications can be targeted. Space-time statistical modeling of data from a large epidemic affecting Cairns, Australia, in 2008-2009 revealed a complex pattern of transmission driven primarily by human mobility (Cairns accounted for ~60% of virus transmission to and from residents of satellite towns, and

SUBMITTER: Vazquez-Prokopec GM 

PROVIDER: S-EPMC5315446 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature