Psychological and behavioural impact of returning personal results from whole-genome sequencing: the HealthSeq project.

ABSTRACT: Providing ostensibly healthy individuals with personal results from whole-genome sequencing could lead to improved health and well-being via enhanced disease risk prediction, prevention, and diagnosis, but also poses practical and ethical challenges. Understanding how individuals react psychologically and behaviourally will be key in assessing the potential utility of personal whole-genome sequencing. We conducted an exploratory longitudinal cohort study in which quantitative surveys and in-depth qualitative interviews were conducted before and after personal results were returned to individuals who underwent whole-genome sequencing. The participants were offered a range of interpreted results, including Alzheimer's disease, type 2 diabetes, pharmacogenomics, rare disease-associated varian

SUBMITTER: Sanderson SC 

PROVIDER: S-EPMC5315514 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature