Modulation of motor inhibition by subthalamic stimulation in obsessive-compulsive disorder.

ABSTRACT: High-frequency deep brain stimulation of the subthalamic nucleus can be used to treat severe obsessive-compulsive disorders that are refractory to conventional treatments. The mechanisms of action of this approach possibly rely on the modulation of associative-limbic subcortical-cortical loops, but remain to be fully elucidated. Here in 12 patients, we report the effects of high-frequency stimulation of the subthalamic nucleus on behavior, and on electroencephalographic responses and inferred effective connectivity during motor inhibition processes involved in the stop signal task. First, we found that patients were faster to respond and had slower motor inhibition processes when stimulated. Second, the subthalamic stimulation modulated the amplitude and delayed inhibition-related electroe

SUBMITTER: Kibleur A 

PROVIDER: S-EPMC5315551 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature