Brain network reorganization differs in response to stress in rats genetically predisposed to depression and stress-resilient rats.

ABSTRACT: Treatment-resistant depression (TRD) remains a pressing clinical problem. Optimizing treatment requires better definition of the specificity of the involved brain circuits. The rat strain bred for negative cognitive state (NC) represents a genetic animal model of TRD with high face, construct and predictive validity. Vice versa, the positive cognitive state (PC) strain represents a stress-resilient phenotype. Although NC rats show depressive-like behavior, some symptoms such as anhedonia require an external trigger, i.e. a stressful event, which is similar to humans when stressful event induces a depressive episode in genetically predisposed individuals (gene-environment interaction). We aimed to distinguish neurobiological predisposition from the depressogenic pathology at the level of br

SUBMITTER: Gass N 

PROVIDER: S-EPMC5315561 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature