The impact of co-existing immune-mediated diseases on phenotype and outcomes in inflammatory bowel diseases.

ABSTRACT:

Background

Inflammatory bowel diseases lead to progressive bowel damage and need for surgery. While the increase in prevalence of other immune-mediated diseases in IBD is well recognised, the impact of this on the natural history of IBD is unknown.

Aim

To determine the impact of concomitant immune-mediated diseases on phenotypes and outcomes in IBD.

Methods

Patients with IBD enrolled in a prospective registry were queried about the presence of other immune-mediated diseases, defined as those where immune dysregulation plays a role in pathogenesis. Demographics and disease-related information were obtained. Subjects also completed measures of quality of life. Multivariable regression models compared disease phenotype and outcomes of IBD patients with and without other

SUBMITTER: Conway G 

PROVIDER: S-EPMC5315585 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature