Contribution of K_V1.5 Channel to Hydrogen Peroxide-Induced Human Arteriolar Dilation and Its Modulation by Coronary Artery Disease.

ABSTRACT:

Rationale

Hydrogen peroxide (H₂O₂) regulates vascular tone in the human microcirculation under physiological and pathophysiological conditions. It dilates arterioles by activating large-conductance Ca²⁺-activated K⁺ channels in subjects with coronary artery disease (CAD), but its mechanisms of action in subjects without CAD (non-CAD) when compared with those with CAD remain unknown.

Objective

We hypothesize that H₂O₂-elicited dilation involves different K⁺ channels in non-CAD versus CAD, resulting in an altered capacity for vasodilation during disease.

Methods and results

H₂O₂ induced endothelium-independent vasodilation in non-CAD adipose arterioles, which was reduced b

SUBMITTER: Nishijima Y 

PROVIDER: S-EPMC5315616 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature