Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis.

ABSTRACT:

Objectives

The mechanism(s) for septic cardiomyopathy in humans is not known. To address this, we measured messenger RNA alterations in hearts from patients who died from systemic sepsis, in comparison to changed messenger RNA expression in nonfailing and failing human hearts.

Design

Identification of genes with altered abundance in septic cardiomyopathy, ischemic heart disease, or dilated cardiomyopathy, in comparison to nonfailing hearts.

Setting

ICUs at Barnes-Jewish Hospital, St. Louis, MO.

Patients

Twenty sepsis patients, 11 ischemic heart disease, nine dilated cardiomyopathy, and 11 nonfailing donors.

Interventions

None other than those performed as part of patient care.

Measurements and main results

Messenger RNA expression levels for 198 m

SUBMITTER: Matkovich SJ 

PROVIDER: S-EPMC5315660 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature