Towards a Model-Based Dose Recommendation for Doxorubicin in Children.

ABSTRACT: Following the publication of our paper regarding a population-based model of doxorubicin pharmacokinetics in children in Clinical Pharmacokinetics last year (Voller et al. 54:1139-1149, 2015), we have received many inquiries on the practical clinical consequences of this model; however, a population-based model is only one of the aspects to be taken into account when developing dosing algorithms. In addition, any new method of dose calculation would need clinical validation and, subsequently, a new clinical trial. However, such a trial, especially with regard to burden to the children involved, requires optimal preparation and the selection of the best hypotheses. The European Paediatric Oncology Off-Patent Medicines Consortium (EPOC), represented by the authors, would therefore like to in

SUBMITTER: Voller S 

PROVIDER: S-EPMC5315724 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature