Biomarkers of acute appendicitis: systematic review and cost-benefit trade-off analysis.

ABSTRACT:

Background

Acute appendicitis is the most common surgical emergency and can represent a challenging diagnosis, with a negative appendectomy rate as high as 20 %. This review aimed to evaluate the clinical utility of individual biomarkers in the diagnosis of appendicitis and appraise the quality of these studies.

Methods

A systematic review of the literature between January 2000 and September 2015 using of PubMed, OvidMedline, EMBASE and Google Scholar was conducted. Studies in which the diagnostic accuracy, statistical heterogeneity and predictive ability for severity of several biomarkers could be elicited were included. Information regarding costs and process times was retrieved from the regional laboratory. European surgeons blinded to these reviews were independently ask

SUBMITTER: Acharya A 

PROVIDER: S-EPMC5315733 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature