Transcriptomic dynamics of breast cancer progression in the MMTV-PyMT mouse model.

ABSTRACT:

Background

Malignant breast cancer with complex molecular mechanisms of progression and metastasis remains a leading cause of death in women. To improve diagnosis and drug development, it is critical to identify panels of genes and molecular pathways involved in tumor progression and malignant transition. Using the PyMT mouse, a genetically engineered mouse model that has been widely used to study human breast cancer, we profiled and analyzed gene expression from four distinct stages of tumor progression (hyperplasia, adenoma/MIN, early carcinoma and late carcinoma) during which malignant transition occurs.

Results

We found remarkable expression similarity among the four stages, meaning genes altered in the later stages showed trace in the beginning of tumor progression. We

SUBMITTER: Cai Y 

PROVIDER: S-EPMC5316186 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature