Inhibition of Monoamine Oxidase by Stilbenes from Rheum palmatum.

ABSTRACT: Seven stilbenes and one catechin were bioactivity-guidedly isolated from the rhizomes of Rheum palmatem. Their structures were identified as piceatannol (1), resveratrol (2), piceid (3), rhapontigenin (4), piceatannol-3´-O-β-D-glucopyranoside (5), rhaponticin (6), catechin (7) and desoxyrhapontigenin (8). Anti-monoamine oxidase (MAO) activities of compounds 1-8 were tested. Compounds 1 and 8 showed significant MAO inhibitory activities with IC₅₀ values 16.4 ± 1.5 μM and 11.5 ± 1.1, respectively, when the IC₅₀ value of iproniazid as a standard was 6.5 ± 0.5 μM. The selectivity of compounds 1-8 against MAO-A and MAO-B were also evaluated. The results showed that compounds 4˴6˴8 preferred to inhibit MAO-A rather than MAO-B with selectivity values ([IC₅

SUBMITTER: Wei B 

PROVIDER: S-EPMC5316268 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature