Identification of Pediatric Patients With Celiac Disease Based on Serology and a Classification and Regression Tree Analysis.

ABSTRACT:

Background & aims

Celiac disease is detected using serology and endoscopy analyses. We used multiple statistical analyses of a geographically isolated population in the United States to determine whether a single serum screening can identify individuals with celiac disease.

Methods

We performed a retrospective study of 3555 pediatric patients (18 years old or younger) in the intermountain West region of the United States from January 1, 2008, through September 30, 2013. All patients had undergone serologic analyses for celiac disease, including measurement of antibodies to tissue transglutaminase (TTG) and/or deamidated gliadin peptide (DGP), and had duodenal biopsies collected within the following year. Modified Marsh criteria were used to identify patients with celiac dise

SUBMITTER: Ermarth A 

PROVIDER: S-EPMC5316297 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature