The impact of red blood cell storage duration on tissue oxygenation in cardiac surgery.

ABSTRACT:

Objective

Although storage alters red blood cells, several recent, randomized trials found no differences in clinical outcomes between patients transfused with red blood cells stored for shorter versus longer periods of time. The objective of this study was to see whether storage impairs the in vivo ability of erythrocytes to traverse the microcirculation and deliver oxygen at the tissue level.

Methods

A subset of subjects from a clinical trial of cardiac surgery patients randomized to receive transfusions of red blood cells stored ≤10 days or ≥21 days were assessed for thenar eminence and cerebral tissue hemoglobin oxygen saturation (S_tO₂) via the use of near-infrared spectroscopy and sublingual microvascular blood flow via side-stream darkfield videom

SUBMITTER: Stowell CP 

PROVIDER: S-EPMC5316299 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature