Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy.

ABSTRACT:

Background

Diabetic cardiomyopathy is a major risk factor in diabetic patients but its pathogenesis remains poorly understood. The ubiquitin-proteasome system (UPS) facilitates protein quality control by degrading unnecessary and damaged proteins in eukaryotic cells, and dysfunction of UPS is implicated in various cardiac diseases. However, the overall functional status of the UPS and its pathophysiological role in diabetic cardiomyopathy have not been determined.

Methods and results

Type I diabetes was induced in wild-type and transgenic mice expressing a UPS functional reporter (GFPdgn) by injections of streptozotocin (STZ). STZ-induced diabetes progressively impaired cardiac UPS function as evidenced by the accumulation of GFPdgn proteins beginning two weeks after diabete

SUBMITTER: Li J 

PROVIDER: S-EPMC5316366 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature