Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression.

ABSTRACT:

Background & aims

Aging is known to exacerbate the progression of alcoholic liver disease (ALD), but the underlying mechanisms remain obscure. The aim of this study was to use a chronic plus binge ethanol feeding model in mice to evaluate the effects of aging on alcohol-induced liver injury.

Methods

C57BL/6 mice were subjected to short-term (10days) ethanol plus one binge or long-term (8weeks) ethanol plus multiple binges of ethanol. Liver injury and fibrosis were determined. Hepatic stellate cells (HSCs) were isolated and used in in vitro studies.

Results

Middle-aged (12-14months) and old-aged (>16months) mice were more susceptible to liver injury, inflammation, and oxidative stress induced by short-term plus one binge or long-term plus multiple binges of ethanol fee

SUBMITTER: Ramirez T 

PROVIDER: S-EPMC5316497 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature