Participant-Informant Relationships Affect Quality of Life Ratings in Incipient and Clinical Alzheimer Disease.

ABSTRACT:

Objective

Clinical trials in incipient and clinical Alzheimer disease (AD) often include informant-reported outcomes. Whereas informant reports in AD dementia may be modulated by the nature of participant-informant relationships, whether informant type affects reporting at earlier disease stages is less certain. We sought to determine the effects of participant-informant relationships on informant assessments of quality of life (QOL), functional abilities, and behavioral symptoms in individuals with normal cognition (NC), mild cognitive impairment (MCI), and mild-to-moderate AD dementia.

Design

Cross-sectional.

Setting

Easton Center for Alzheimer Disease Research at the University of California, Los Angeles.

Participants

A total of 399 individuals who met crite

SUBMITTER: Lin A 

PROVIDER: S-EPMC5316499 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature