Volumetric quantification of absolute local normalized helicity in patients with bicuspid aortic valve and aortic dilatation.

ABSTRACT:

Purpose

Absolute local normalized helicity (LNH) can differentiate flow alterations in the aorta between healthy controls and bicuspid aortic valve (BAV) patients.

Methods

A total of 65 controls and 50 subjects with BAV underwent in vivo four-dimensional (4D) flow MRI. Data analysis included the three-dimensional (3D) segmentation of the thoracic aorta (ascending aorta, aortic arch, and descending aorta) and calculation of absolute LNH. The mean velocity in the entire aorta was used to identify peak systole, systolic deceleration, and middiastole. A sensitivity analysis was performed to identify the optimal absolute LNH threshold, comparing control and BAV groups. A reproducibility test was performed for 3D segmentation and absolute LNH.

Results

Absolute LNH above 0.6

SUBMITTER: Garcia J 

PROVIDER: S-EPMC5316512 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature