A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity.

ABSTRACT: The selective transformation of different starting materials by different metal catalysts under individually optimized reaction conditions to structurally different intermediates and products is a powerful approach to generate diverse molecular scaffolds. In a more unified albeit synthetically challenging strategy, common starting materials would be exposed to a common metal catalysis, leading to a common intermediate and giving rise to different scaffolds by tuning the reactivity of the metal catalyst through different ligands. Herein we present a ligand-directed synthesis approach for the gold(I)-catalysed cycloisomerization of oxindole-derived 1,6-enynes that affords distinct molecular scaffolds following different catalytic reaction pathways. Varying electronic properties and the steri

SUBMITTER: Lee YC 

PROVIDER: S-EPMC5316858 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature