Ontology highlight
ABSTRACT:
SUBMITTER: Harmanc? AS
PROVIDER: S-EPMC5316884 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Nature communications 20170214
Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared benign meningiomas to atypical ones. Here, we show that the majority of primary (de novo) atypical meningiomas display loss of NF2, which co-occurs either with genomic instability or recurrent SMARCB1 mutations. These tumours harbour increased H3K27me3 signal and a hypermethylated phenotype, mainly occupying t ...[more]