Massively augmented hippocampal dentate granule cell activation accompanies epilepsy development.

ABSTRACT: In a mouse model of temporal lobe epilepsy, multicellular calcium imaging revealed that disease emergence was accompanied by massive amplification in the normally sparse, afferent stimulation-induced activation of hippocampal dentate granule cells. Patch recordings demonstrated reductions in local inhibitory function within the dentate gyrus at time points where sparse activation was compromised. Mimicking changes in inhibitory synaptic function and transmembrane chloride regulation was sufficient to elicit the dentate gyrus circuit collapse evident during epilepsy development. Pharmacological blockade of outward chloride transport had no effect during epilepsy development, and significantly increased granule cell activation in both control and chronically epileptic animals. This apparent

SUBMITTER: Dengler CG 

PROVIDER: S-EPMC5316990 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature