S 38093, a histamine H₃ antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice.

ABSTRACT: Strategies designed to increase adult hippocampal neurogenesis (AHN) may have therapeutic potential for reversing memory impairments. H₃ receptor antagonists/inverse agonists also may be useful for treating cognitive deficits. However, it remains unclear whether these ligands have effects on AHN. The present study aimed to investigate the effects of a 28-day treatment with S 38093, a novel brain-penetrant antagonist/inverse agonist of H₃ receptors, on AHN (proliferation, maturation and survival) in 3-month-old and in aged 16-month-old mice. In addition, the effects of S 38093 treatment on 7-month-old APPSWE Tg2576 transgenic mice, a model of Alzheimer's disease, were also assessed. In all tested models, chronic treatment with S 38093 stimulated all steps of AHN. In ag

SUBMITTER: Guilloux JP 

PROVIDER: S-EPMC5317168 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature