Using CdTe/ZnSe core/shell quantum dots to detect DNA and damage to DNA.

ABSTRACT: CdTe/ZnSe core/shell quantum dot (QD), one of the strongest and most highly luminescent nanoparticles, was directly synthesized in an aqueous medium to study its individual interactions with important nucleobases (adenine, guanine, cytosine, and thymine) in detail. The results obtained from the optical analyses indicated that the interactions of the QDs with different nucleobases were different, which reflected in different fluorescent emission maxima and intensities. The difference in the interaction was found due to the different chemical behavior and different sizes of the formed nanoconjugates. An electrochemical study also confirmed that the purines and pyrimidines show different interactions with the core/shell QDs. Based on these phenomena, a novel QD-based method is developed to de

SUBMITTER: Moulick A 

PROVIDER: S-EPMC5317249 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature