Ontology highlight
ABSTRACT:
SUBMITTER: Rudin CM
PROVIDER: S-EPMC5317279 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
The New England journal of medicine 20090902 12
Medulloblastoma is the most common malignant brain tumor in children. Aberrant activation of the hedgehog signaling pathway is strongly implicated in the development of some cases of medulloblastoma. A 26-year-old man with metastatic medulloblastoma that was refractory to multiple therapies was treated with a novel hedgehog pathway inhibitor, GDC-0449; treatment resulted in rapid (although transient) regression of the tumor and reduction of symptoms. Molecular analyses of tumor specimens obtaine ...[more]