TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype.

ABSTRACT:

Objective

To interrogate a poly-T variant (rs10524523, '523) in TOMM40, a gene adjacent to the APOE gene on chromosome 19, in older persons with APOE ε3/3 homozygosity for association with cognitive decline, the clinical hallmark of Alzheimer disease (AD).

Methods

Data came from participants in 2 cohort studies of aging and dementia who underwent annual clinical evaluations for up to 21 years. APOE and TOMM40'523 genotypes were determined from DNA from blood or brain samples. Linear mixed models compared the rates of decline in cognition among APOE ε3/3 carriers with different '523 genotypes.

Results

The 1,170 APOE ε3/3 homozygotes were of European ancestry, were free of dementia at baseline, and had an average age of 7

SUBMITTER: Yu L 

PROVIDER: S-EPMC5317377 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature