TDP-43 pathology and memory impairment in elders without pathologic diagnoses of AD or FTLD.

ABSTRACT:

Objective

To investigate the association of TAR DNA-binding protein 43 (TDP-43) pathology with memory, other cognitive domains, and dementia in community-dwelling elders without pathologic diagnoses of Alzheimer disease (AD) or frontotemporal lobar degeneration (FTLD).

Methods

Of 1,058 autopsied participants, 343 (32.4%) did not have pathologic diagnoses of AD or FTLD. Diagnosis of dementia was based on clinical evaluation and cognitive performance tests, which were used to create summary measures of global cognition and of 5 cognitive domains. TDP-43 pathology evaluated in 6 brain regions by immunohistochemistry was converted into a summary measure of TDP-43 severity.

Results

Of 343 participants, 135 (39.4%) had TDP-43 pathology with a mean TDP-43 severity score of 0

SUBMITTER: Nag S 

PROVIDER: S-EPMC5317379 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature