Leukoaraiosis, intracerebral hemorrhage, and functional outcome after acute stroke thrombolysis.

ABSTRACT:

Objective

To perform a systematic review and pooled meta-analysis of published studies to assess whether the presence of leukoaraiosis on neuroimaging before treatment with thrombolysis (IV or intra-arterial) is associated with an increased risk of symptomatic intracerebral hemorrhage (sICH) or poor functional outcome.

Methods

We included studies of patients with acute ischemic stroke, treated with IV or intra-arterial thrombolysis, which assessed functional outcome (3-month modified Rankin Scale [mRS]) or sICH in relation to leukoaraiosis on pretreatment neuroimaging (CT or MRI). We used random-effects models to calculate pooled relative risks (RR) of sICH and poor functional outcome (mRS ≥ 2) for any vs no leukoaraiosis (using any rating scale) and for no to mild vs modera

SUBMITTER: Kongbunkiat K 

PROVIDER: S-EPMC5317383 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature