Genome-wide association study identifies MAPT locus influencing human plasma tau levels.

ABSTRACT:

Objective

To identify genetic loci associated with plasma tau concentrations in healthy elders and individuals with Alzheimer disease.

Methods

Four hundred sixty-three non-Hispanic white individuals exceeding quality control criteria were included from the Alzheimer's Disease Neuroimaging Initiative (ADNI-1) cohort. Association of plasma tau with genetic polymorphisms was performed with a linear regression model. Significant associations were validated in an independent replication cohort consisting of 431 healthy elders or individuals with mild cognitive impairment recruited from the University of California, San Francisco Memory and Aging Center.

Results

The minor allele (A) of rs242557 in the microtubule-associated protein tau gene (MAPT) was associated with

SUBMITTER: Chen J 

PROVIDER: S-EPMC5317386 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature