Glucose level decline precedes dementia in elderly African Americans with diabetes.

ABSTRACT:

Introduction

High blood glucose levels may be responsible for the increased risk for dementia in diabetic patients.

Methods

A secondary data analysis merging electronic medical records (EMRs) with data collected from the Indianapolis-Ibadan Dementia project (IIDP). Of the enrolled 4105 African Americans, 3778 were identified in the EMR. Study endpoints were dementia, mild cognitive impairment (MCI), or normal cognition. Repeated serum glucose measurements were used as the outcome variables.

Results

Diabetic participants who developed incident dementia had a significant decrease in serum glucose levels in the years preceding the diagnosis compared to the participants with normal cognition (P = .0002). They also had significantly higher glucose levels up to 9 years befo

SUBMITTER: Hendrie HC 

PROVIDER: S-EPMC5318260 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature