Current status of biomarker and targeted nanoparticle development: The precision oncology approach for pancreatic cancer therapy.

ABSTRACT: Pancreatic cancer remains one of the major causes of cancer-related mortality. The majority of pancreatic cancer patients are diagnosed at the advanced stage with unresectable and drug resistant tumors. The new treatments with the combination of chemotherapy, molecular targeted therapy, and immunotherapy have shown modest effects on therapeutic efficacy and survival of the patients. Therefore, there is an urgent need to develop effective therapeutic approaches targeting highly heterogeneous pancreatic cancer cells and tumor microenvironments. Recent advances in biomarker targeted cancer therapy and image-guided drug delivery and monitoring treatment response using multifunctional nanoparticles, also referred to as theranostic nanoparticles, offer a new opportunity of effective detection an

SUBMITTER: Zhu L 

PROVIDER: S-EPMC5318282 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature