Childhood maltreatment, psychopathology, and the development of hippocampal subregions during adolescence.

ABSTRACT:

Introduction

It is well established that childhood maltreatment has a detrimental impact on the brain, particularly the hippocampus. However, the hippocampus is a functionally and structurally heterogeneous region, and little is known about how maltreatment might affect hippocampal subregion development throughout important periods of plasticity. This study investigated whether childhood maltreatment was associated with the development of hippocampal subregion volumes from early to late adolescence. It also investigated associations between onset of psychiatric disorder and hippocampal subregion volume development.

Methods

One hundred and sixty-six (85 male) adolescents took part in three magnetic resonance imaging assessments during adolescence (mean age at each assessment:

SUBMITTER: Whittle S 

PROVIDER: S-EPMC5318361 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature