Disrupted neural activity patterns to novelty and effort in young adult APOE-e4 carriers performing a subsequent memory task.

ABSTRACT:

Introduction

The APOE e4 allele has been linked to poorer cognitive aging and enhanced dementia risk. Previous imaging studies have used subsequent memory paradigms to probe hippocampal function in e4 carriers across the age range, and evidence suggests a pattern of hippocampal overactivation in young adult e4 carriers.

Methods

In this study, we employed a word-based subsequent memory task under fMRI; pupillometry data were also acquired as an index of cognitive effort. Participants (26 non-e4 carriers and 28 e4 carriers) performed an incidental encoding task (presented as word categorization), followed by a surprise old/new recognition task after a 40 minute delay.

Results

In e4 carriers only, subsequently remembered words were linked to increased hippocampal activit

SUBMITTER: Evans S 

PROVIDER: S-EPMC5318365 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature