Reproducibility of tract-based white matter microstructural measures using the ENIGMA-DTI protocol.

ABSTRACT:

Background

In preparation for longitudinal analyses of white matter development in youths with family histories of substance use disorders (FH+) or without such histories (FH-), we examined the reproducibility and reliability of global and regional measures of fractional anisotropy (FA) values, measured using the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA)-diffusion tensor imaging (DTI) protocol. Highly reliable measures are necessary to detect any subtle differences in brain development.

Methods

First, we analyzed reproducibility data in a sample of 12 healthy young adults (ages 20-28) imaged three times within a week. Next, we calculated the same metrics in data collected 1-year apart in the sample of 68 FH+ and 21 FH- adolescents. This is a timeframe w

SUBMITTER: Acheson A 

PROVIDER: S-EPMC5318368 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature