Identifying Candidate Genes that Underlie Cellular pH Sensitivity in Serotonin Neurons Using Transcriptomics: A Potential Role for Kir5.1 Channels.

ABSTRACT: Ventilation is continuously adjusted by a neural network to maintain blood gases and pH. Acute CO₂ and/or pH regulation requires neural feedback from brainstem cells that encode CO₂/pH to modulate ventilation, including but not limited to brainstem serotonin (5-HT) neurons. Brainstem 5-HT neurons modulate ventilation and are stimulated by hypercapnic acidosis, the sensitivity of which increases with increasing postnatal age. The proper function of brainstem 5-HT neurons, particularly during post-natal development is critical given that multiple abnormalities in the 5-HT system have been identified in victims of Sudden Infant Death Syndrome. Here, we tested the hypothesis that there are age-dependent increases in expression of pH-sensitive ion channels in brainstem 5-H

SUBMITTER: Puissant MM 

PROVIDER: S-EPMC5318415 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature